Jason M. Ridlon

This study identifies novel 17β-hydroxysteroid dehydrogenases in Peptoniphilus and Anaerococcus that convert androstenedione to testosterone, expanding understanding of microbial androgen metabolism in the genitourinary tract.

The study identifies Actinobaculum massiliense as a urinary pathobiont capable of generating androgens via the dirAB pathway, using a novel HSDH assay.

This study quantitatively characterizes the kinetic parameters and substrate specificity of the NADPH-dependent 17α-hydroxysteroid dehydrogenase encoded by the desF gene in Clostridium scindens VPI 12708, revealing its role in epitestosterone formation.

This study identifies the group B [FeFe]-hydrogenase as the primary enzyme driving fermentative H2 production in the human gut, linking it to gut health and disease.

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

This study analyzes the pangenome of 34 C. scindens strains and 200 MAGs to understand genetic variability and functional roles in bile acid and steroid metabolism.

This paper examines the role of Clostridium scindens in bile acid and steroid metabolism, questioning its taxonomic classification and suggesting future genetic studies.