H. Rex Gaskins

This study identifies novel 17β-hydroxysteroid dehydrogenases in Peptoniphilus and Anaerococcus that convert androstenedione to testosterone, expanding understanding of microbial androgen metabolism in the genitourinary tract.

The study identifies Actinobaculum massiliense as a urinary pathobiont capable of generating androgens via the dirAB pathway, using a novel HSDH assay.

This study identifies the group B [FeFe]-hydrogenase as the primary enzyme driving fermentative H2 production in the human gut, linking it to gut health and disease.

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.