Author

Ismayn A. Ditter

Oregon Health & Science UniversityORCID 0000-0001-5814-2026Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adam C. OkeniD· 1 shared Haoyuan ShiiD· 1 shared Steven E. MansooriD· 1 shared

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2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Adam C. OkenORCID

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1 paper

Recent·Most cited

BiochemistryScience AdvancesPeer-reviewedJan 17, 2025

Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket

Haoyuan Shi, Ismayn A. Ditter, Adam C. Oken, Steven E. Mansoor

The paper reports cryo-EM structures of human P2X4 receptor in different states, revealing the cytoplasmic cap forms before agonist binding and is stabilized by lipids, with unique allosteric features for modulator development.

14 citationstop 1%

humancryo-EM

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