Author

Haoyuan Shi

Oregon Health & Science UniversityORCID 0000-0002-1822-6230Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Adam C. OkeniD· 1 shared Amelie AndreasiD· 1 shared Ankita J. SachlaiD· 1 shared Arthur GlasfeldiD· 1 shared Ismayn A. DitteriD· 1 shared John D. HelmanniD· 1 shared Keikilani Miller· 1 shared Ritu ShresthaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Adam C. OkenORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMar 5, 2025

Structural basis for transcription activation through cooperative recruitment of MntR

Haoyuan Shi, Yu Fu, Vilmante Kodyte…·Shivani Ahuja

This study determines the structural basis of MntR-mediated gene activation through cooperative DNA binding using cryo-EM and complementary assays.

13 citationstop 3%

bacteria (other)structural biology

𝕏 PostBluesky

BiochemistryScience AdvancesPeer-reviewedJan 17, 2025

Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket

Haoyuan Shi, Ismayn A. Ditter, Adam C. Oken, Steven E. Mansoor

The paper reports cryo-EM structures of human P2X4 receptor in different states, revealing the cytoplasmic cap forms before agonist binding and is stabilized by lipids, with unique allosteric features for modulator development.

14 citationstop 1%

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