Adam C. Oken

This paper identifies UB-ALT-P2, a P2X7R antagonist that reduces Alzheimer's disease pathology in mice by improving memory, reducing amyloid-beta and tau, and decreasing inflammation.

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.

The paper reports cryo-EM structures of human P2X4 receptor in different states, revealing the cytoplasmic cap forms before agonist binding and is stabilized by lipids, with unique allosteric features for modulator development.