12/15-Lipoxygenase orchestrates murine wound healing via PPARg-activating oxylipins acting holistically to dampen inflammation.
Christopher P. Thomas, Victoria J. Tyrrell, James J. Burston, Sam R. C. Johnson, Maceler Aldrovandi, Jorge Álvarez-Jarreta, Rossa Inglis, Adam Leonard, Lydia Fice, Jeremie Costales, Antonio Vidal‐Puig, Majd B. Protty, Carol Guy, Robert Andrews, Barbara Szomolay, , Valerie B. O’Donnell
Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.
Proceedings of the National Academy of Sciences · Sep 4, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest