Tomohiro Miyasaka

This study investigates how phosphorylation patterns in the proline-rich region of Tau affect its microtubule-binding dynamics in neurons using FRAP and computational modeling.

This study identifies the S/P region of MAP2 as critical for its localization in dendrites, revealing that cytoplasmic dynein-mediated transport maintains this localization through an intermittent active transport mechanism.

The paper shows that soluble wild-type tau in presynaptic terminals causes microtubule assembly, which sequesters dynamin and impairs vesicle endocytosis and neurotransmission in an Alzheimer's disease model.

The paper develops an experimental system for proper axonal tau localization and identifies phosphorylation of the proline-rich region 2 as critical for this process.

This study shows that ectopic expression of human tau in mice leads to abnormal somatodendritic distribution, while knock-in mice show normal axonal localization due to developmental expression patterns.