Akihiko Takashima

This study identifies Praja1 as an E3 ligase that ubiquitinates and degrades Tau, a key protein in tauopathies, and shows evolutionary conservation of this interaction.

This study identifies plexin-B3+ oligodendrocyte precursor cells as potential amyloid beta-secreting cells in Alzheimer's disease.

This study shows that ectopic expression of human tau in mice leads to abnormal somatodendritic distribution, while knock-in mice show normal axonal localization due to developmental expression patterns.