Geoffrey Fudenberg

The paper reviews polymer models and experimental evidence supporting loop extrusion as a mechanism for chromosome folding, focusing on CTCF and cohesin perturbations in interphase.

This paper proposes that loop extrusion by cohesins and boundary proteins like CTCF forms Topologically Associating Domains (TADs) through dynamic loop creation and stabilization.

The paper uses polymer simulations to show that chromatin loops can either insulate or facilitate enhancer-promoter interactions, depending on their location relative to the pair.