Maxime M. C. Tortora

Chromosome folding encodes mechanisms of cohesion maintenance

The paper shows how changes in sister chromatid folding over time encode mechanisms of cohesion maintenance, revealing how transient cofactor interactions regulate long-lived cohesin protection.

The physical chemistry of interphase loop extrusion

The paper develops a minimal model of cohesin loop extrusion based on biochemical and biophysical data, showing how regulatory protein dynamics influence genome folding.

Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption

The paper shows that the extrusion rate of cohesin is tunable by cofactor dosage and buffers chromosome structure against genetic disruption.

Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

The paper develops a dynamic barrier model to explain genome folding features using biophysically measured CTCF and cohesin dynamics, showing that barrier bound times influence ChIP-seq, Hi-C, and chromosome morphology.

DNA replication and polymer chain duplication reshape the genome in space and time

The paper develops a computational framework to model DNA replication dynamics and their impact on chromosome organization, showing replication-dependent loop extrusion and sister chromatid interactions in yeast.