Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation
Lin Zhang, Arnold Bolomsky, Omar S. Al‐Odat, Callie K. VanWinkle, Aaliyah Battle, Papiya Chakraborty, Ronald J. Holewinski, Þorkell Andrésson, Björn Häupl, Thomas Oellerich, Elizabeth Hill, Mehmet Hakan Kocoglu, Qingcai Meng, James D. Phelan, Jagan R. Muppidi, Ryan M. Young
This study identifies phosphorylation as a mechanism protecting oncogenic RAS from LZTR1-mediated degradation, with implications for targeting RAS stability in hematologic cancers.
Blood Cancer Discovery · Aug 31, 2026Peer-reviewedCancer Biology