Cancer BiologyLeukemiaPeer-reviewed
Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells
Shira G. Glushakow-Smith, Imit Kaur, Simone Sidoli…·Kira Gritsman
This study identifies a resistance mechanism in AML leukemic stem cells to PI3K inhibition and shows that combining PI3K and EZH1/2 inhibitors overcomes resistance.
DOI 10.1038/s41375-026-03145-4