Pharmacology & ToxicologyDrug Metabolism and DispositionPeer-reviewed
Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling
Sejal Sharma, Yik Pui Tsang, Jashvant D. Unadkat
This study identifies cortisol as the main pregnancy-related hormone inducing hepatic transporters OAT2, NTCP, and OCT1 in HepaRG cells via GR, HNF4, and HNF1 signaling.
DOI 10.1016/j.dmd.2026.100383