Keisuke Kaji

The paper reports a method to reprogram primary human hepatocytes into proliferative pre-cHep cells with high expansion potential and liver repopulation capacity, offering an alternative to PHHs for drug testing and disease modeling.

This paper identifies Hic2 as a gene that enhances iPSC generation by suppressing KLF4-dependent epidermal gene expression during reprogramming.

CELLoGeNe maps Boolean gene regulatory networks into energy landscapes to analyze cell fate decisions, identifying attractors in pluripotency maintenance and reprogramming.

The paper introduces an optimized DamID-seq method to map transcription factor occupancy in mammalian cells and embryos using minimal cell numbers.