Masahito Yoshihara

Multi-layered regulatory networks driving human dopaminergic neuron differentiation

The paper integrates multi-omics data to identify regulatory networks driving human dopaminergic neuron differentiation and highlights key transcription factors and enhancer-associated regulators.

Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

This paper identifies Hic2 as a gene that enhances iPSC generation by suppressing KLF4-dependent epidermal gene expression during reprogramming.

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

The paper investigates how primary cilia influence human neuron differentiation via the WNT signaling pathway, identifying a critical 'ciliary time window' for axon development.

Dog color patterns explained by modular promoters of ancient canid origin

The paper identifies regulatory modules controlling dog color patterns and shows their evolutionary origin in extinct canids.

Differentiation of ciliated human midbrain-derived LUHMES neurons

The paper introduces LUHMES, a ciliated human neuronal cell model, and shows its utility for studying cilia biology and ciliopathies across neuronal development.

DUX4 regulates oocyte to embryo transition in human

This study shows that DUX4 regulates the oocyte-to-embryo transition in humans by activating enhancers and promoting genome reprogramming.