Linh Huynh

The paper reports a method to reprogram primary human hepatocytes into proliferative pre-cHep cells with high expansion potential and liver repopulation capacity, offering an alternative to PHHs for drug testing and disease modeling.

This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.

The paper identifies an enhancer cluster that drives SOX2 overexpression in breast and lung cancer by altering chromatin accessibility and regulatory mechanisms.