Nicola Festuccia

This study investigates how GATA6, a pioneer transcription factor, drives Primitive Endoderm differentiation by remodeling chromatin and interacting with other TFs.

This study shows Nr5a2 is essential for morula development in mice, as its absence causes embryonic arrest, lineage specification issues, and genome instability.

The paper shows that redundancy among nuclear receptor bookmarking factors ensures robust reactivation of pluripotency genes after mitosis.

The paper shows that CTCF mitotic bookmarking enables rapid post-mitotic gene reactivation in ES cells, with some genes being sensitive to CTCF depletion.

This study shows that Esrrb and Nr5a2 are essential for maintaining naive pluripotency in mouse ESCs by regulating the pluripotency network and preventing differentiation.

The paper shows that CTCF and Esrrb maintain nucleosome positioning at gene regulatory regions during DNA replication and mitosis in mouse ES cells.

The paper investigates how transcription factors maintain gene regulatory information during mitosis by comparing fixation methods and analyzing nucleosome organization.