Agnès Dubois

MYC and MAX drive the reactivation of the genome after mitosis

This study identifies MYC and MAX as critical for post-mitotic genome reactivation in pluripotent mouse embryonic stem cells, showing MAX's role in bookmarking and MYC recruitment.

Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling

This study maps positive DNA supercoiling across interphase and mitosis, revealing its role in transcriptional control and genome architecture.

Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation

This study investigates how GATA6, a pioneer transcription factor, drives Primitive Endoderm differentiation by remodeling chromatin and interacting with other TFs.

Mitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.

The paper shows that redundancy among nuclear receptor bookmarking factors ensures robust reactivation of pluripotency genes after mitosis.

H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate

The paper identifies H3K9me3 at the Nanog locus as a repressive mark that marks differentiation commitment and enables primitive endoderm fate acquisition in ES cells.

OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

Mitotic bookmarking by CTCF controls selected genes during the fast post-mitotic genome reactivation of ES cells

The paper shows that CTCF mitotic bookmarking enables rapid post-mitotic gene reactivation in ES cells, with some genes being sensitive to CTCF depletion.

The combined action of Esrrb and Nr5a2 is essential for naive pluripotency.

This study shows that Esrrb and Nr5a2 are essential for maintaining naive pluripotency in mouse ESCs by regulating the pluripotency network and preventing differentiation.

CTCF confers local nucleosome resiliency after DNA replication and during mitosis

The paper shows that CTCF and Esrrb maintain nucleosome positioning at gene regulatory regions during DNA replication and mitosis in mouse ES cells.

The molecular logic of Nanog-induced self-renewal

This study shows how Nanog uses different mechanisms to enhance embryonic stem cell self-renewal by rewiring pluripotency networks and blocking differentiation through histone modification.

Transcription factor activity and nucleosome organisation in mitosis

The paper investigates how transcription factors maintain gene regulatory information during mitosis by comparing fixation methods and analyzing nucleosome organization.