James R. Goldenring

A unique intestinal epithelial cell that expresses canonical lymphoid genes

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

PKA/CIP4 SIGNALING REGULATES CIP4 RELOCATION IN ACTIVATED NATURAL KILLER CELLS

This study identifies PKA/CIP4 signaling as a mechanism controlling CIP4 relocalization during NK cell activation, showing phosphorylation at T225 regulates its spatial distribution.

Coronavirus membrane protein with a fluorescent protein tag enables tracking of virus particles in live cells

This paper develops a fluorescently labeled coronavirus by tagging the M protein with GFP to study intracellular trafficking and egress in live cells.

CLASP1/2 REGULATE IMMUNE SYNAPSE MATURATION IN NATURAL KILLER CELLS

This study shows that CLASP1/2 stabilize Golgi-derived microtubules in NK cells, facilitating LFA-1 trafficking and immune synapse maturation.

Cryo-EM of AKAP350 reveals fibrillar clusters and a potential association with DNA

This study uses cryo-EM to show AKAP350 forms fibrillar clusters and interacts with DNA and DNA-binding proteins like NFIB and NCL.

Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation

This study shows that MYO5B defects disrupt lipid metabolism and mitochondrial structure in intestinal epithelial cells, and that LPAR5 activation with Compound-1 can partially reverse these defects and improve intestinal function in MVID models.