Grzegorz Ira

The paper investigates templated insertions at DNA breaks in yeast, showing they are short, inverted duplications formed via a hybrid mechanism involving RPA and Rad27, and are exacerbated in certain mutants.

The paper investigates the role of yeast EndoG (Nuc1) in preventing genome instability by degrading cytoplasmic DNA and regulating its transfer to the nucleus.

The paper identifies proteins and mechanisms that suppress mutagenic Break-Induced Replication (BIR) during repair of two-ended DNA double-strand breaks.

This study identifies Rad52, Rad59, Srs2, and the MRX complex as essential for Rad51-independent single-strand template repair in yeast, showing distinct genetic requirements compared to Rad51-dependent repair.