Qian Li

This study creates a cattle transcriptome BodyMap across 52 tissues and 3 developmental stages, identifying lncRNAs and RNA editing sites linked to beef production traits.

OneGenome-Rice (OGR) is a genomic foundation model for rice pre-trained on 422 genomes, outperforming existing models in 11 tasks and enabling downstream applications like trait analysis and gene expression prediction.

GPTAnno provides a hierarchical cell type annotation method using GPT models and ontology trees, improving accuracy across species and tissues by integrating clustering with ontology constraints.

The paper creates a temporal and spatial atlas of postnatal heart development using single-nucleus transcriptomics and spatial transcriptomics, identifying 21 novel regulators of cardiomyocyte maturation through a new method called PIP-seq.

This study identifies novel tRNA modifications in Plasmodium falciparum using an optimized sequencing protocol, revealing dynamic changes during development and stress.

The paper investigates templated insertions at DNA breaks in yeast, showing they are short, inverted duplications formed via a hybrid mechanism involving RPA and Rad27, and are exacerbated in certain mutants.

The paper investigates the role of yeast EndoG (Nuc1) in preventing genome instability by degrading cytoplasmic DNA and regulating its transfer to the nucleus.

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

iSMNN improves batch effect correction in scRNA-seq by iteratively refining mutual nearest neighbors, enhancing cell type mixing and differential gene identification across batches.

This study shows that pulmonary B cells reduce Alzheimer's disease-like pathology in mice by decreasing beta-amyloid production and improving cognitive function.

The paper identifies molecular diversity in adult hippocampal and entorhinal cells, revealing cell-type-specific properties related to Alzheimer's disease vulnerability.