James E. Haber

The paper identifies Mrc1/Claspin as a novel regulator of DSB repair independent of the Mec1 checkpoint, showing it promotes DSB survival through end-tethering and limiting resection.

The paper identifies Esc1-mediated telomere anchoring as a mechanism regulating telomere clustering in yeast during metabolic shifts to quiescence.

The paper studies mutations and structural variants during double-strand break repair in budding yeast, finding that repair-associated deletions and template switches depend on microhomology and homeology.

This study shows that DNA polymerase δ proofreading nuclease inhibits translesion synthesis and promotes recombination during DNA lesion bypass.

This study shows that prolonged cell cycle arrest in yeast after DNA damage requires both DNA damage checkpoint (DDC) and spindle assembly checkpoint (SAC) proteins, with a handoff from DDC to SAC components after 15 hours.

The paper investigates mutation mechanisms during homologous recombination in yeast, showing that mismatch repair suppresses quasipalindrome and frameshift mutations during double-strand break repair.

The paper develops MAGESTIC 3.0, a CRISPR-based system for genome-wide variant installation in yeast, revealing missense variants and multiple causal variants in quantitative trait loci across environmental conditions.

This paper introduces two methods to detect recurrent genomic rearrangements in cancer genomes and identifies 80 simple and 29 complex rearrangements across 2,500 cancers.

The paper investigates mutation patterns during double-strand break repair in yeast, finding that deletions and tandem duplications occur with specific microhomology preferences and structural constraints.

The paper shows that CAG/CTG repeats in ssDNA gaps influence repair kinetics, leading to repeat expansions or contractions and chromosome breaks.

The paper identifies the Mediator Kinase Module's role in DNA damage response and transcriptional regulation across species.

This paper investigates how nonhomologous tails influence heteroduplex rejection and mismatch correction during SSA in yeast, showing that tails stimulate rejection and affect correction mechanisms.

This study investigates how mismatched donor templates affect Rad51-dependent break-induced replication in budding yeast, finding that BIR efficiency depends on thermodynamics and DNA polymerase proofreading.

This study identifies HULC and Set1C as factors that regulate heterochromatin organization during mating-type switching in fission yeast by controlling recombination enhancer usage and histone modifications.

The paper investigates how nucleosome dynamics and eviction after a double-strand break are reversible via NHEJ repair in yeast, showing re-establishment of chromatin structure in G1-arrested cells.

The paper identifies proteins and mechanisms that suppress mutagenic Break-Induced Replication (BIR) during repair of two-ended DNA double-strand breaks.

The paper identifies TADs as functional units in DDR, showing cohesin-mediated loop extrusion contributes to {gamma}H2AX/53BP1 domain formation during DSB repair.

This study shows that phospho-mimetic H2A-S129E increases chromatin mobility and modulates DNA damage response by altering chromosomal conformation.

This study identifies Rad52, Rad59, Srs2, and the MRX complex as essential for Rad51-independent single-strand template repair in yeast, showing distinct genetic requirements compared to Rad51-dependent repair.

The paper analyzes whole-genome sequencing data from cancer samples to identify genomic footprints of telomere maintenance mechanisms, finding specific telomere variant repeat patterns associated with ATRX/DAXX mutations.

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.

The paper uses fluorescent markers to study DSB formation and repair dynamics in yeast, finding that DSB foci coalesce and dissociate without requiring Rad2 protein.

The paper investigates CRISPR-Cas9 cleavage in yeast and human cells, revealing templated insertions and strand-specific indel patterns influenced by gRNA orientation and repair factors.

The paper analyzes somatic rearrangements in cancer genomes using whole-genome sequencing data, identifying recurrent breakpoints and their genomic features.

The paper investigates how the location of a donor sequence and centromere anchoring affect intrachromosomal repair of a double-strand break in budding yeast.