Marek Bartkuhn

PGC-1α Links Estrogen Receptor Signaling to Japanese Encephalitis Virus Replication in Neuronal cell

This study shows estrogen enhances Japanese Encephalitis Virus replication in neuronal cells via the ER-PGC-1 axis and identifies it as a potential target for sex-specific therapies.

Mitochondrial COX4I2 drives pericyte-dependent inflammation and emphysema

This study shows that COX4I2 in pericytes drives inflammation and emphysema in COPD by increasing mtROS, and its deletion protects against these effects.

Depletion of CX3CR1+ macrophages results in disrupted functionality and immune surveillance within epididymis and testis

This study shows that CX3CR1+ macrophages are essential for maintaining immune balance and epithelial integrity in the epididymis and testis, with their depletion leading to immune dysfunction and fertility issues.

Human heart organoids reveal a regenerative strategy for mitochondrial disease

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution

This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.

Endothelial expression of ZBTB16 protects against cardiac aging

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

The proximity-based protein interaction landscape of the transcription factor p65 NF-kappaB/RELA and its gene-regulatory logics

The paper identifies >350 p65/RELA interactors and reveals gene regulatory networks controlled by RELA and its interactors in the IL-1 response.

Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical Models

This study evaluates the antifibrotic effects of OTR4120 in lung fibrosis models, showing reduced collagen deposition and fibroblast activation.

ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner

This study identifies ZNF512B as a repressor of gene expression that interacts with the NuRD complex via a conserved motif and can cause chromatin aggregation independently of NuRD.

A common gene signature of the right ventricle in failing rat and human hearts

The paper identifies a conserved gene signature associated with right ventricular failure in both rat and human hearts through transcriptomic analysis and validation.

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.

Comprehensive Genomic Features indicative for Notch Responsiveness

The paper identifies genomic features associated with Notch responsiveness by analyzing RBPJ binding dynamics and develops a machine learning approach to predict Notch responsiveness in different cellular contexts.

The H2A.Z.1/PWWP2A/NuRD-associated protein HMG20A controls early head and heart developmental transcription programs

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.