J. Tabitha Hees

The paper shows that PINK1 precursor translation in neurons requires ER and endolysosome interaction, with DNAJB6 facilitating its transport to mitochondria for mitophagy.

This study shows insulin signaling modulates AMPK activity to regulate Pink1 mRNA localization, affecting PINK1 function in neurons and linking insulin resistance to mitochondrial dysfunction.

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

This study identifies compounds that promote axon regeneration using human iPSC-derived motor neurons and validates blebbistatin as a top hit in vivo.