Shreyas Balachandra Rao

This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.

The paper shows reduced astrocytic Ca2+ signaling and uncoupling from pupil responses in Alzheimer's disease mice during awake behavior.