Neurosciencenpj AgingPeer-reviewed
Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging
Beatriz Escobar-Doncel, Xiaoyi Zhang, Åsne Ljøstad…·Wannan Tang
This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.