Beatriz Escobar-Doncel

This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.

This study identifies myosin misfolding as a driver of HCM using a fluorescent reporter and C. elegans model, showing dietary restrictions can reverse defects via autophagy.

The paper shows NAD+ and EVA1-C regulate alternative splicing in tauopathies, affecting protein interactions and disease progression, suggesting therapeutic potential for AD.