Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging
Beatriz Escobar-Doncel, Xiaoyi Zhang, Åsne Ljøstad, Mario Fernández de la Puebla, Shreyas Balachandra Rao, Synnøve Algrøy Fjeldstad, M. Dahle, Mahmood Reza Amiry-Moghaddam, Magnar Bjørås, Wannan Tang
This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.
npj Aging · May 26, 2026Peer-reviewedNeuroscience