Author

Mikhail Vysotskiy

Innovative Genomics InstituteORCID 0000-0003-1307-2874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David N. NguyeniD· 2 shared Lauren A. WeissiD· 2 shared Alexander MarsoniD· 1 shared Alissa LW Kleinhez· 1 shared Angela E. RiversiD· 1 shared Atip LawanprasertiD· 1 shared Brenna J. GittinsiD· 1 shared Charlotte H. WangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

David N. NguyenORCID

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4 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 31, 2026

LNP-mediated BCL11A Editing Corrects Sickling Phenotypes and Preserves HSPC Fitness Compared to Electroporation

Yaw Ofosu Nyansa Ansong‐Ansongton, Corynne Stéphanie Ahouéfa Adanho, Utku Goreke…·David N. Nguyen

This study compares LNP and electroporation for delivering CRISPR to HSPCs, finding LNPs provide better cell viability and HbF induction with lower toxicity.

DOI 10.64898/2026.08.26.747413

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintApr 29, 2026

CRISPR-mediated functional mapping of IL2RG variants in primary human T cells predicts X-linked severe combined immunodeficiency

Yvonne Rong, Mikhail Vysotskiy, Peixin Amy Chen…·David N. Nguyen

The paper uses CRISPR to assess the functional impact of IL2RG variants in human T cells, confirming known annotations and identifying novel loss-of-function mutations.

DOI 10.64898/2026.04.27.26351884

humanCRISPR screen

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Genetic & Genomic MedicinePLoS GeneticsPeer-reviewedJun 2, 2023

Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits

Mikhail Vysotskiy, Lauren A. Weiss

The paper investigates how combinations of genes in the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits by comparing pairwise and single-gene effects in GWAS data.

7 citations

humanGWAS summary statistics

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GeneticsbioRxivPreprintJun 23, 2020

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Mikhail Vysotskiy, Xue Yun Zhong, Tyne W. Miller‐Fleming…·Lauren A. Weiss

The paper integrates genetic, transcriptomic, and clinical data to identify CNV gene associations with brain-related and health traits, finding pleiotropy and multigenicity in CNV biology.

2 citations

humanGWAS summary statistics

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