Tyne W. Miller‐Fleming

MarkerMatch: A Proximity-Based Probe-Matching Algorithm for Joint Analysis of Copy-Number Variants from Different Genotyping Arrays

MarkerMatch improves CNV detection sensitivity across genotyping arrays by matching probes based on proximity, outperforming consensus probe methods.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

Common variant approaches to study Mendelian disease gene function identify novel phenome and pathways associated with PLOD3

Genetics of cardiovascular outcomes in individuals with chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study

The paper performs GWAS on cardiovascular outcomes in CKD patients, identifying stroke-associated SNVs but not replicating CHD findings, and finding genetic correlations with published GWAS.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

T-SEM of 11 Major Psychiatric Disorders: Identification of Gene Expression Patterns for Cross-Disorder Risk and Drug Repurposing

This study uses T-SEM to identify gene expression patterns linked to genetic overlap and disorder-specific risk in psychiatric disorders, finding potential drug repurposing targets.

Genes associated with depression and coronary artery disease are enriched for inflammation and cardiomyopathy-associated pathways.

This study identifies genes associated with both depression and coronary artery disease that are enriched for inflammation and cardiomyopathy pathways, and finds higher prevalence of cardiomyopathy in individuals with comorbid depression-CAD.

Genetic Examination of Hematological Parameters in SARS-CoV-2 Infection and COVID-19

This study examines the genetic links between baseline hematological parameters and risk of SARS-CoV-2 infection and severe COVID-19 using Mendelian randomization and GWAS data.

Analyses of Biomarker Traits in Diverse UK Biobank Participants Identify Associations Missed by European-centric Analysis Strategies

The paper identifies novel genetic associations for biomarker traits in non-European UK Biobank populations, highlighting missed signals in European-centric analyses.

Transcriptional control of parallel-acting pathways that remove discrete presynaptic proteins in remodeling neurons

The paper identifies a transcriptional pathway regulated by IRX-1 that drives the removal of presynaptic proteins during neuronal remodeling in C. elegans.

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

This study identifies 59 sentinel variants and two novel genes associated with telomere length using whole genome sequences from 109,122 trans-ethnic individuals.

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

Genome-wide association study and integrative analyses identify 27 genes in inflammation and coagulation pathways linked to COVID-19 hospitalization risk and symptomology.

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

The paper integrates genetic, transcriptomic, and clinical data to identify CNV gene associations with brain-related and health traits, finding pleiotropy and multigenicity in CNV biology.