Sarah E. Waye

The paper uses single-cell RNA sequencing to show that mice adapt to small bowel resection by reprogramming distal intestinal enterocytes to a proximal identity, driven by retinoid metabolism and Creb3l3.

This paper introduces a lineage-tracing method called CellTagging to study clonal dynamics in direct lineage reprogramming from fibroblasts to induced endoderm progenitors, revealing rare successful reprogramming events and clonal instability.