Andrew J.R. Plested

The paper identifies CNIH3 as a molecular marker for slow AMPA receptors in specific hippocampal regions and demonstrates its role in modulating synaptic responses.

This study investigates the atomistic mechanisms of calcium permeation in GluA2 AMPA receptors, showing how Q/R editing and selectivity filter mutations modulate ion selectivity and conductance.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

This paper introduces SPARCLS, a high-speed 3D random-access scanning method achieving 340 kHz point rate, and demonstrates its application in imaging synaptic events in mammalian and zebrafish models.

The paper introduces two improved fluorescent glutamate sensors, iGlu3Fast and iGlu3Slow, with distinct kinetic properties for imaging glutamate activity in the brain.

The paper develops postsynaptic-targeted glutamate sensors to improve specificity and reliability of synaptic transmission measurements.

This study investigates how Con-ikot-ikot toxin affects AMPA-type glutamate receptors at the single-channel level, showing it blocks desensitization but poorly stabilizes the open channel.

The paper identifies slow AMPA receptors in mouse hippocampal principal cells that remain active for up to half a second, enhancing charge transfer and action potential triggering.

The paper uses unnatural amino acid mutagenesis to study conformational changes in the TMD of AMPA receptors, revealing interactions critical for activation and desensitization.