Estelle Toulmé

The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.

This study identifies two distinct regions in the synaptotagmin-1/SNARE complex interface that mediate different functions in neurotransmitter release and shows that Ca2+ triggers a rearrangement of this interface.

The paper identifies specific amino acid residues in the complexin N-terminus that differentially affect spontaneous and evoked neurotransmitter release in hippocampal neurons.

The paper develops synthetic binders specific to PSD-95 for imaging endogenous proteins with minimal impact on function and compatibility with super-resolution techniques.

The paper develops postsynaptic-targeted glutamate sensors to improve specificity and reliability of synaptic transmission measurements.

The paper reveals a nanoscale tripartite complex at glutamatergic synapses formed by Ca2+-channels, vesicles, and AMPA receptors, showing their functional coordination in neurotransmission.