Author

Maria Claudia Villegas Kcam

Rice UniversityORCID 0000-0001-6062-9423Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1

Frequent Co-Authors

James ChappelliD· 2 shared Andrea AmeruosoiD· 1 shared Annette J. TsongiD· 1 shared Katherine Piper Cohen· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersSynthetic Biology

James ChappellORCID

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2 papers

Recent·Most cited

Synthetic BiologyNucleic Acids ResearchPeer-reviewedJul 8, 2022

Activating natural product synthesis using CRISPR interference and activation systems in Streptomyces

Andrea Ameruoso, Maria Claudia Villegas Kcam, Katherine Piper Cohen, James Chappell

This paper develops CRISPRi and CRISPRa systems in Streptomyces to activate silent biosynthetic gene clusters for antibiotic discovery.

66 citationstop 1%

bacteria (other)experimental assay

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedJan 25, 2022

Uncovering the distinct properties of a bacterial type I-E CRISPR activation system

Maria Claudia Villegas Kcam, Annette J. Tsong, James Chappell

This study develops a bacterial CRISPRa system using type I-E CRISPR-Cas, showing distinct activation range and periodicity compared to type II systems.

9 citations

bacteria (other)CRISPR screen

𝕏 PostBluesky