Meng Li

This study corrects a dominant BEST1 mutation in patient-derived RPE cells using base editing, showing improved cellular function and transcriptome normalization.

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

The study identifies histone modifications H4K8ac and H4K20me3 that regulate transcriptional differences between adult and neonatal oligodendrocyte progenitors.