Jian Xu

The paper shows that growth-mediated compressive stresses drive millimeter-scale gap closure in MEC1 cells, with fluid-like tissue remodeling enhancing collective closure.

This study identifies PRMT1-SFPQ as a regulator of intron retention in craniofacial development, leading to reduced matrix gene expression through NMD.

This study compares the biological and biomechanical features of mandibular condylar cartilage and articular cartilage in mice, revealing distinct structural and functional differences.

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

The paper identifies TGF-β signaling and Creb5 as regulators of Fgf18 in perimysial fibroblasts, which is essential for pharyngeal muscle development in mice.

This study identifies Kdm6b's role in regulating p53 signaling during palatogenesis by enabling Tfdp1 to activate p53 expression through chromatin accessibility.

The paper develops a combined chemical and immunoaffinity approach to profile protein methylation, identifying novel PRMT1 targets and revealing dynamic interactions between methyltransferases.

This study shows BMP signaling is required for MSC lineage commitment and identifies downstream transcription factors that determine cellular identities in dental mesenchyme.