Patrizia Casaccia

Epigenomic regulation of human oligodendrocyte myelination properties, relation to age and lineage

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning

The paper shows safety learning in the infralimbic cortex recruits oligodendrocyte progenitor cells to PV interneurons, promoting PNN degradation and cognitive flexibility.

PDGF-BB overexpression in p53 null oligodendrocyte progenitors increases H3K27me3 and induces transcriptional changes which favor proliferation

This study shows that PDGF-BB overexpression in p53 null OPCs increases H3K27me3 and promotes proliferation by altering transcription.

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

The paper uses iPSC-derived glia cultures from MS patients to identify glia-intrinsic disease mechanisms and potential therapeutic targets.

The epigenetic landscape of oligodendrocyte progenitors changes with time

The study identifies histone modifications H4K8ac and H4K20me3 that regulate transcriptional differences between adult and neonatal oligodendrocyte progenitors.

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

TET1-mediated DNA hydroxy-methylation regulates adult remyelination

This study shows that TET1-mediated DNA hydroxy-methylation is essential for adult remyelination, with loss of function leading to impaired myelin repair in aged mice.

PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelination

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.