Jiang Qian

Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

Lignature: A Comprehensive Database of Ligand Signatures to Predict Cell-Cell Communication

Lignature is a database of ligand-induced transcriptomic signatures that improves prediction of active ligands compared to existing methods like NicheNet.

Single-Cell Proteomic and Transcriptomic Characterization of Drug-Resistant Prostate Cancer Cells Reveals Molecular Signatures Associated with Morphological Changes

This study uses single-cell proteomics and RNA-seq to analyze drug-resistant prostate cancer cells, identifying proteomic sub-clusters and gene expression changes linked to morphological and functional traits.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

Axon Guidance Signaling Modulates Epithelial to Mesenchymal Transition in Stem Cell-Derived Retinal Pigment Epithelium

This study investigates EMT in stem cell-derived RPE cells, identifying dysregulated axon guidance molecules during the process.