BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Context-Dependent Variability Of HIF Heterodimers Influences Interactions With Macromolecular And Small Molecule Partners
Joseph D. Closson, Xingjian Xu, Meiling Zhang…·Kevin H. Gardner
This study investigates how context-dependent variability in HIF heterodimers affects their interactions with DNA, small molecules, and coactivators, revealing a novel 'dimer-of-heterodimers' structure.
DOI 10.1073/pnas.2514042123