Author

Barbara Bosch

Rockefeller UniversityORCID 0000-0001-7708-6461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jeremy M. RockiD· 2 shared Alain FischeriD· 1 shared Alain Lefèvre‐UtileiD· 1 shared Alexander Antipenko· 1 shared Alexandre BolzeiD· 1 shared Allison FayiD· 1 shared Andréanne LupieniD· 1 shared Andrew John PollardiD· 1 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

Jeremy M. RockORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintDec 10, 2025

Chlorotonils exhibit potent activity against Mycobacterium tuberculosis, while resistance is mediated by MmpR5-MmpL5

Felix Deschner, Melissa Dalcina Chengalroyen, Lauren Ames…·Jennifer E. Herrmann

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

1 citation

humanwhole-genome sequencing

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MicrobiologybioRxivPreprintNov 14, 2025

The phenotypic landscape of the mycobacterial cell

Nadia Herrera, Horia Todor, Lili M. Kim…·Carol A. Gross

The paper performs a genome-wide CRISPRi screen in Mycobacterium smegmatis to uncover novel gene functions and drug targets related to the cell envelope.

4 citations

bacteria (other)genetic perturbation / CRISPR

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BiophysicsNature Structural & Molecular BiologyPeer-reviewedJan 8, 2025

RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation

Joshua J. Brewer, Koe Inlow, Rachel Anne Mooney…·Seth Andrew Darst

The paper shows RapA disrupts post-termination complexes in E. coli to prevent R-loop formation and maintain genome stability.

4 citations

E. colistructural biology

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedAug 2, 2018

Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons

Alexandre Bolze, Bertrand Boisson, Barbara Bosch…·Jean‐Laurent Casanova

The paper reports new RPSA mutations causing isolated congenital asplenia, including 5-UTR mutations and incomplete penetrance in some cases.

44 citations

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