Paola Pizzo

The paper develops a computational model of mitochondrial bioenergetics and integrates it with experimental data from Parkinson's Disease models to predict molecular defects and provide a resource for interpreting bioenergetic experiments.

This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

The paper investigates lipid droplet (LD) metabolism in an AD model and finds altered LD dynamics contribute to mitochondrial dysfunction and cell dyshomeostasis.