Alvin P. Joselin

This study shows that mitochondrial proteostasis stress causes a biphasic cortisol response, with mild stress increasing and severe stress decreasing cortisol production, linking mitochondrial function to steroidogenesis in Parkinson's disease models.

This study identifies VDAC1 as a regulator of DJ-1's mitochondrial matrix localization, showing its role in maintaining mitochondrial homeostasis and neuronal survival under stress.

The paper develops a computational model of mitochondrial bioenergetics and integrates it with experimental data from Parkinson's Disease models to predict molecular defects and provide a resource for interpreting bioenergetic experiments.

This study shows that reducing CDK14 genetically or pharmacologically decreases alpha-synuclein pathology and improves symptoms in Parkinson's disease models.

This study identifies PFTK1's role in axogenesis by regulating RhoA phosphorylation and activity during CNS development in Drosophila and mice.