Brian J. Nieman

This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.

In 14 BXD mouse strains, those modelling developmental coordination disorder have relatively larger cortex and smaller cerebellar/subcortical volumes; this axis tracks motor coordination but maps to no single QTL.

The paper quantifies gonadal and sex chromosome dosage contributions to sex differences in brain volume across multiple regions in mice, revealing their combined effects on anatomical and cellular gene expression.

This study examines the effects of prenatal THC exposure on mouse brain development using MRI across the lifespan, finding sex-dependent neurodevelopmental impacts.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

This study identifies Tmod2 as a regulator of cocaine-induced plasticity and addiction-related behaviors through effects on neuronal excitability and synaptic function.

This study characterizes a mouse model with TDP-43 M323K mutation, showing cognitive, motor, and structural brain abnormalities linked to TDP-43 mislocalization and increased levels.

This paper introduces a knock-in mouse model of ATR-X syndrome carrying a common patient mutation, showing craniofacial defects, microcephaly, and impaired neurological function.

This study shows that the FUSDelta14 mutation causes neurodevelopmental and systemic metabolic issues in mice, including brain structural abnormalities and metabolic pathway changes.

The paper uses MRI and Bayesian hierarchical modeling to show that immune dysfunction in mice affects specific brain regions and correlates with anxiety-like behaviors.

This study examines how early or late prenatal maternal immune activation affects mouse embryo brain development, finding distinct neuroanatomical changes depending on exposure timing.

This study shows that maternal high-fat diet exposure leads to persistent brain changes in adult offspring, affecting regions linked to neurodevelopmental disorders.

This study investigates the effects of early and late prenatal maternal immune activation on neonatal neurodevelopment using behavioral and MRI assessments, finding subtle impacts on communication and brain anatomy.

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.

The paper investigates structural covariance in mouse brain regions, finding that it is explained by distance, transcriptomic similarity, and connectivity, with varying contributions across brain areas.

The paper uses MRI to show male-specific brain areas develop earlier than female-specific ones in mice across postnatal development.