Author

Cassandra A. L. Simonich

Seattle Children's HospitalORCID 0000-0001-6100-4652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Jesse D. BloomiD· 2 shared Teagan E. McMahoniD· 2 shared Alexander L. GreningeriD· 1 shared Gavin JuvileriD· 1 shared Helen Y. ChuiD· 1 shared Lucas KampmaniD· 1 shared Michael BoeckhiD· 1 shared Natalie BrunetteiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Jesse D. BloomORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

MicrobiologyNaturePeer-reviewedSep 16, 2026

Mutational constraints on RSV F and its neutralization by antibodies

Cassandra A. L. Simonich, Teagan E. McMahon, Gavin Juviler…·Jesse D. Bloom

This study defines how mutations in RSV F protein affect antibody neutralization and shows that resistance to nirsevimab is rare but possible.

DOI 10.1038/s41586-026-11030-4

biophysical modelinghost-pathogen & immune response

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedJul 3, 2025

RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera

Cassandra A. L. Simonich, Teagan E. McMahon, Xiaohui Ju…·Jesse D. Bloom

This study shows RSV F evolution can escape some monoclonal antibodies but does not strongly reduce neutralization by human polyclonal sera, and introduces a tool to measure neutralization against RSV strains.

15 citationstop 1%

humanexperimental assay

𝕏 PostBluesky