Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins
Xiaohui Ju, William W. Hannon, Tomasz Kaszuba, Caelan E. Radford, Brendan B. Larsen, Samantha S. Nelson, Christopher A. Nelson, Israel Baltazar-Perez, Ofer Zimmerman, Daved H. Fremont, Michael Diamond, Jesse D. Bloom
This study identifies amino-acid mutations in CHIKV envelope proteins that affect entry in human and mosquito cells, revealing species-specific determinants of viral tropism.
bioRxiv · Aug 25, 2025 · PreprintMicrobiology