Author

Anna Lechner

ORCID 0000-0001-6127-9314Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Bethany K. OkadaiD· 2 shared Gabriella Costa Machado da CruziD· 2 shared Mark J. BurkiD· 2 shared Peter A. JordaniD· 2 shared Rajan R. ChaudhariiD· 2 shared Christopher J. RosarioiD· 1 shared Fumiya K. SanoiD· 1 shared Hiroaki AkasakaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Bethany K. OkadaORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of the American Chemical SocietyPeer-reviewedSep 2, 2025

Overcoming Immune Checkpoint Inhibitor Resistance via Potent and Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso Peptides

Anna Lechner, Peter A. Jordan, Gabriella Costa Machado da Cruz…·Mark J. Burk

7 citations

mouseproteomics

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedApr 22, 2025

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

Wataru Shihoya, Hiroaki Akasaka, Peter A. Jordan…·Osamu Nureki

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

9 citations

𝕏 PostBluesky