Leslie Dale

The paper identifies molecular differences in chick embryo regions that lack competence for neural induction, showing that BMP inhibition and ERK stimulation can restore competence in some areas but not others.

The paper uses single-cell and tissue transcriptomics to show the organizer is a diverse collection of signaling cell sub-populations, not a single homogeneous population.

The paper constructs a gene regulatory network for neural induction using transcriptomics and epigenomics data, revealing 175 regulators and 5,614 interactions with temporal dynamics.