Alexandre P Thiery

The paper assesses axial patterning in human inner ear organoids and finds incomplete and disorganized regionalisation, suggesting limitations in self-organization and potential strategies to enhance cell complexity in vitro.

The paper identifies genes and regulatory networks involved in shark tooth regeneration using RNAseq, highlighting the role of mycn in dental stem cell proliferation.

The paper uses scATAC-seq to study chromatin accessibility changes during neural plate border cell fate specification, identifying new regulatory mechanisms involving Foxk2.

The paper uses single-cell RNA sequencing to study cell fate decisions at the neural plate border in chick ectoderm, proposing a gradient border model for fate allocation.

The paper constructs a gene regulatory network for neural induction using transcriptomics and epigenomics data, revealing 175 regulators and 5,614 interactions with temporal dynamics.

The paper identifies Sox8 as a key transcription factor that remodels cranial ectoderm to generate ear progenitors and activate ear development programs.

The paper shows that an enamel knot-like signalling centre is conserved in sharks, supporting its homology across vertebrates despite differences in signalling.

This study investigates the developmental mechanisms of pufferfish skin spines, showing they develop through conserved gene interactions but lack EDA, a key molecule in other vertebrate skin appendages.