Inducible activation of PKA in osteoblasts causes a profound high bone turnover phenotype similar to human diseases
Carole Le Hénaff, Zhiming He, Joshua H. Johnson, Johanna Warshaw, Rocco Latorre, Nigel W. Bunnett, Despina Sitara, Lawrence Steven Kirschner, Henry M. Kronenberg, Nicola C. Partridge
This study shows that inducible PKA activation in osteoblasts leads to high bone turnover and disease-like phenotypes in mice.
bioRxiv · Mar 13, 2026 · PreprintPathology