Rocco Latorre

This paper introduces SynPARs, synthetic protease-activated receptors that enable cells to sense and respond to protease activity, demonstrating their use in counteracting hyperalgesia in mice.

This study shows that inducible PKA activation in osteoblasts leads to high bone turnover and disease-like phenotypes in mice.

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.

This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.